منابع مشابه
Human minor histocompatibility antigens.
Disparities in minor histocompatibility antigens between HLA-matched organ and bone marrow donors and recipients create a potential risk for graft failure and graft-versus-host disease. These conditions necessitate lifelong pharmacological immunosuppression of organ and bone marrow transplant recipients. Recent technical advances have resulted in the identification of the chemical nature of the...
متن کاملMinor histocompatibility antigens.
ISTOCOMPATIBILITY antigens are a group of cell H membrane alloantigens that can trigger T-lymphocyte proliferative and/or cytolytic activity in vitro and may initiate graft rejection or graft-versus-host disease (GVHD) in vivo. AB0 and related antigens, whose presence on vascular endothelial cells may provoke antibody-mediated graft rejection, are excluded from this group because they do not in...
متن کاملHapMap scanning of novel human minor histocompatibility antigens.
Minor histocompatibility antigens (mHags) are molecular targets of allo-immunity associated with hematopoietic stem cell transplantation (HSCT) and involved in graft-versus-host disease, but they also have beneficial antitumor activity. mHags are typically defined by host SNPs that are not shared by the donor and are immunologically recognized by cytotoxic T cells isolated from post-HSCT patien...
متن کاملPolymorphism of human minor histocompatibility antigens: T cell recognition of human minor histocompatibility peptides presented by HLA- B35 subtype molecules
To investigate the polymorphism of human minor histocompatibility (mH) antigens, PBLs from 23 Japanese individuals and 25 German individuals with HLA-B35 were studied by using four human mH antigen-specific, HLA-B35-restricted CTL clones. The CTL clones killed PHA-stimulated PBLs from all 23 Japanese individuals. On the other hand, they killed the PHA-stimulated PBLs from 19 of 25 German indivi...
متن کاملConservation of minor histocompatibility antigens between human and non-human primates.
It is well accepted that minor histocompatibility antigens (mHag) can function as transplantation barriers between HLA-matched individuals. Little is known about the molecular nature and evolutionary conservation of mHag. It is only very recently that the first human mHag were identified. The HLA-A2.1-restricted mHag HA-2 and the HLA-B7-restricted mHag H-Y appeared to be peptides derived from p...
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ژورنال
عنوان ژورنال: Transplant Immunology
سال: 1993
ISSN: 0966-3274
DOI: 10.1016/0966-3274(93)90056-e